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Microbial Cell Factories

 http://www.microbialcellfactories.com/

GENOMIC DIVERSITY AND MEIOTIC RECOMBINATION AMONG ISOLATES OF THE BIOTECH YEAST KOMAGATAELLA PHAFFII

Komagataella phaffii is a yeast widely used in the pharmaceutical and biotechnology industries, and is one of the two species that...

GREEN PYOMELANIN-MEDIATED SYNTHESIS OF GOLD NANOPARTICLES: MODELLING AND DESIGN, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

Synthesis of nanoparticles and their incorporation in materials are amongst the most studied topics in chemistry, physics and material...

 
 
 

COMBINED ARTIFICIAL HIGH-SILICATE MEDIUM AND LED ILLUMINATION PROMOTE CAROTENOID ACCUMULATION IN THE MARINE DIATOM PHAEODACTYLUM TRICORNUTUM

Diatoms, which can accumulate large amounts of carotenoids, are a major group of microalgae and the dominant primary producer in marine...

FHL1P PROTEIN, A POSITIVE TRANSCRIPTION FACTOR IN PICHIA PASTORIS, ENHANCES THE EXPRESSION OF RECOMBINANT PROTEINS

The methylotrophic yeast Pichia pastoris is well-known for the production of a broad spectrum of functional types of heterologous proteins...

 
 
 

ADVANCES AND OPPORTUNITIES IN GENE EDITING AND GENE REGULATION TECHNOLOGY FOR YARROWIA LIPOLYTICA

Yarrowia lipolytica has emerged as a biomanufacturing platform for a variety of industrial applications. It has been demonstrated to...

PHOSPHATE REGULATOR PHOP DIRECTLY AND INDIRECTLY CONTROLS TRANSCRIPTION OF THE ERYTHROMYCIN BIOSYNTHESIS GENES IN SACCHAROPOLYSPORA ERYTHRAEA

The choice of phosphate/nitrogen source and their concentrations have been shown to have great influences on antibiotic production....

 
 
 

EFFICIENT CAS9-BASED GENOME EDITING OF RHODOBACTER SPHAEROIDES FOR METABOLIC ENGINEERING

Rhodobacter sphaeroides is a metabolically versatile bacterium that serves as a model for analysis of photosynthesis, hydrogen production...

INTEGRATION OF A MULTI-STEP HETEROLOGOUS PATHWAY IN SACCHAROMYCES CEREVISIAE FOR THE PRODUCTION OF ABSCISIC ACID

The sesquiterpenoid abscisic acid is mostly known for regulating developmental processes and abiotic stress responses in higher plants....

 
 
 

GROWTH OF THE FACULTATIVE CHEMOLITHOAUTOTROPH RALSTONIA EUTROPHA ON ORGANIC WASTE MATERIALS: GROWTH CHARACTERISTICS, REDOX REGULATION AND HYDROGENASE ACTIVITY

The chemolithoautotrophic β-proteobacterium Ralstonia eutropha H16 is one of the most studied model organisms for growth on H2 and...

SUBSTANTIALLY IMPROVING THE ENANTIOCONVERGENCE OF PVEH1, A PHASEOLUS VULGARIS EPOXIDE HYDROLASE, TOWARDS M-CHLOROSTYRENE OXIDE BY LABORATORY EVOLUTION

Epoxide hydrolase can regioselectively catalyze the oxirane ring-opening hydrolysis of rac-epoxides producing the corresponding chiral...

 
 
 

SYNTHETIC CONTROL DEVICES FOR GENE REGULATION IN PENICILLIUM CHRYSOGENUM

Orthogonal, synthetic control devices were developed for Penicillium chrysogenum, a model filamentous fungus and industrially relevant...

RESTRUCTURED LACTOCOCCUS LACTIS STRAINS WITH EMERGENT PROPERTIES CONSTRUCTED BY A NOVEL HIGHLY EFFICIENT SCREENING SYSTEM

After 2.83% genome reduction in Lactococcus lactis NZ9000, a good candidate host for proteins production was obtained in our previous...

 
 
 

ENGINEERING CYTOPLASMIC ACETYL-COA SYNTHESIS DECOUPLES LIPID PRODUCTION FROM NITROGEN STARVATION IN THE OLEAGINOUS YEAST RHODOSPORIDIUM AZORICUM

Oleaginous yeasts are able to accumulate very high levels of neutral lipids especially under condition of excess of carbon and nitrogen...

LACCASES: STRUCTURE, FUNCTION, AND POTENTIAL APPLICATION IN WATER BIOREMEDIATION

The global rise in urbanization and industrial activity has led to the production and incorporation of foreign contaminant molecules...

 
 
 

ALIIVIBRIO WODANIS AS A PRODUCTION HOST: DEVELOPMENT OF GENETIC TOOLS FOR EXPRESSION OF COLD-ACTIVE ENZYMES

Heterologous production of cold-adapted proteins currently represents one of the greatest bottlenecks in the ongoing bioprospecting...

REDESIGNING THE ASPERGILLUS NIDULANS XYLANASE REGULATORY PATHWAY TO ENHANCE CELLULASE PRODUCTION WITH XYLOSE AS THE CARBON AND INDUCER SOURCE

Biomass contains cellulose , hemicellulose and lignin. Biomass ranks amongst the most abundant hydrocarbon resources on earth. However,...

 
 
 

5-AMINOLEVULINIC ACID FERMENTATION USING ENGINEERED SACCHAROMYCES CEREVISIAE

5′-Aminolevulinic acid is widely used in the pharmaceutical industry, healthcare, and food production, and is a substrate for the biosynthesis...

HIGH PRODUCTION OF VALENCENE IN SACCHAROMYCES CEREVISIAE THROUGH METABOLIC ENGINEERING

The biological synthesis of high value compounds in industry through metabolically engineered microorganism factories has received...

 
 
 

EXTRACELLULAR PRODUCTION OF THE ENGINEERED THERMOSTABLE PROTEASE PERNISINE FROM AEROPYRUM PERNIX K1 IN STREPTOMYCES RIMOSUS

The thermostable serine protease pernisine originates from the hyperthermophilic Archaeaon Aeropyrum pernix and has valuable industrial...

ISOLATION, IDENTIFICATION, AND POTENTIAL PROBIOTIC CHARACTERIZATION OF ISOLATED LACTIC ACID BACTERIA AND IN VITRO INVESTIGATION OF THE CYTOTOXICITY, ANTIOXIDANT, AND ANTIDIABETIC ACTIVITIES IN FERMENTED SAUSAGE

Probiotic bacteria can provide health benefits when delivered in functional foods. This study involved isolation of lactic acid bacteria...

 
 
 



World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

World Biotechnology Congress 2019

Hilaris Conferences is going to host its premier World Biotechnology Congress 2019 during October 01-02, 2019, Valencia, Spain. Biotechnology 2019 Congress aim to create a... Read more ...

2nd International Conference on Tissue Science and Regenerative Medicine

This conference is designed for experts in academia and industries working in the tissue science and regenerative field, this conference will examine cutting-edge research in... Read more ...

Perceptive Unveils New $200M Fund to Invest in Early-Stage Biotechs

Perceptive Unveils New $200M Fund to Invest in Early-Stage Biotechs

Perceptive Advisors, an investment firm with a long track record of life science investing across all points of development, is now stepping up to pump money into companies at... Read more ...

Merck Makes a Big Blood Cancer Bet With $2.7B Deal for ArQule

Merck Makes a Big Blood Cancer Bet With $2.7B Deal for ArQule

Merck is acquiring cancer drug developer ArQule for $2.7 billion , a cash deal that brings it a promising early-stage compound that could challenge a blockbuster leukemia drug... Read more ...

KalVista Pharma Eye Drug Partnered With Merck Flunks Phase 2 Test

KalVista Pharma Eye Drug Partnered With Merck Flunks Phase 2 Test

A KalVista Pharmaceuticals eye drug at the center of a research collaboration with Merck has failed a mid-stage clinical trial. KalVista developed its drug, KVD001, to treat... Read more ...

Zentalis Steps Out With $147M Raised to Develop “Tried and True” Small Molecules

Zentalis Steps Out With $147M Raised to Develop “Tried and True” Small Molecules

Zentalis Pharmaceuticals is banking on small molecules for cancer-leaving the “cool technologies” aside for a “tried and true” approach, says the CEO, who wants to let the... Read more ...

Scripps Research, AbbVie Expand Drug Discovery Deal Beyond Cancer

Scripps Research, AbbVie Expand Drug Discovery Deal Beyond Cancer

The Scripps Research Institute and AbbVie have agreed to broaden an existing drug discovery agreement focused on cancer cell therapies to now encompass treatments for other... Read more ...

Eying Cancer Combos, Sanofi to Splash Out $2.5B on San Diego's Synthorx

Eying Cancer Combos, Sanofi to Splash Out $2.5B on San Diego's Synthorx

Synthorx is working to design new cytokine therapies for cancer using an “extended” genetic alphabet that could help avoid the shortcomings associated with earlier versions... Read more ...

Artificial Pancreas Keeps Patients Healthier: A Perspective

Artificial Pancreas Keeps Patients Healthier: A Perspective

The late Mayo endocrinologists Russell Wilder, M.D., and Randall Sprague, M.D., would be smiling today at the news for patients with diabetes. Much of their lives and careers... Read more ...

Aurinia Plans FDA Filing After Lupus Nephritis Drug Hits Phase 3 Goals

Aurinia Plans FDA Filing After Lupus Nephritis Drug Hits Phase 3 Goals

Aurinia shares spiked last week after voclosporin, an immunosuppressant being tested in patients with lupus nephritis, met its primary and secondary endpoints in a Phase 3... Read more ...

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

AstraZeneca Taps Gatehouse Bio to Identify Potential Drug Targets

After joining AstraZeneca's Boston Bio Hub incubator last year, Gatehouse Bio is now teaming up with the pharma company to identify potential drug targets in respiratory and... Read more ...

Alzheimer's drug candidates reverse broader aging, study shows

LA JOLLA-In mouse models of Alzheimer's disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. Now, Salk... Read more ...